Mechanisms behind the pharmacological application of biochanin-A: a review

This review was aimed at summarizing the cellular and molecular mechanisms behind various pharmacological actions of biochanin-A. Many studies have been reported claiming its application in cancers, metabolic disorders, airway hyperresponsiveness, cardiac neurological etc. With regard to hormone-dependent cancers like breast, prostate, other malignancies pancreatic, colon, lung, osteosarcoma, glioma that has limited treatment options, biochanin-A revealed agreeable results arresting cancer development. Biochanin-A also shown therapeutic benefits when administered for diabetes, hyperlipidaemia, chronic diseases/disorders. Isoflavones are considered phenomenal due their high efficiency modifying physiological functions human body. is one among prominent isoflavones found soy (glycine max), red clover (Trifolium pratense), alfalfa sprouts, etc., with proven potency modulating vital diseases. It popular ages menopausal women controlling symptoms. In view multi-targeted biochanin-A, it essential summarize it's mechanism action disorders. The safety efficacy need be established clinical trials involving subjects. Biochanin-A might able modify systems body cardiovascular system, CNS, respiratory a remarkable effect on hormonal cancers. types research particularly pancreatic positive impact. Through oxidative stress, SIRT-1 expression, PPAR gamma receptors, multiple produces anti-diabetic action. The diverse mechanistic pathways involved ability indicate very promising molecule can play major impact several functions.